ANTIMUTAGENIC EFFECT OF P—AMINOBENZOIC ACID AND SODIUM EISULFITE ON THE MUTAGNICITY OF N-METHYL-N-NITRO-N-NITROSOGUANIDINE
- VernacularTitle:对—氨基苯甲酸与亚硫酸氢钠对甲基硝基亚硝基胍的抗诱变作用
- Author:
Xiaoling YANG
;
Jiwu HUANG
;
Hui YU
- Publication Type:Journal Article
- Keywords:
P-aminobenzoic acid sodium bisulfite;
human lymphocytes;
unscheduled DNA synthesis (UDS)
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Antimutagenic effect of p-aminobenzoic acid (PABA) and sodium bisulfite (NaHSO_3)on the mutagenicity of N-methyl-N-nitro-N-nitrosoguanidine (MNNG) was detected by the mehod of human lymphocytes unscheduled DNA Sythesis (LIDS). The results showed that when the concentration of PABA and NaHSO_3 was varied in presence of a constant concentration of MNNG, 5 ?10~(-5) mol/L concentration of PABA, 3 ? 10~(-4) mol/L concentration of NaHSO_3 were the most effective, while the concentration of MNNG varied in the presence of a constant concentration of PABA and NaHSO_3, antimutagenicity was the most effective at high concentration of MNNG. The results indicated that the PABA and NaHSO_3 exhibited antimutagenic activity towards MNNG-induced mutagenicity in LIDS and the extents of antimutagenicity were related with the concentration of MNNG.
