Inhibitory effect of Gwe on mutagenesis induced by Cyclophosphomide
- VernacularTitle:Gwe对环磷酰胺诱变的对抗效应
- Author:
Xiuying LU
- Publication Type:Journal Article
- Keywords:
Gwe;
Micronucleus;
Chromosome aberrrations;
Sister—chromatid exchange;
IL—6
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Gwe is a new immunological response modifier extracted from a traditional Chinese drug.In our experiments,we demonstrated that:1.Gwe could significantely inhibite micronucleus fre-quencies in bone marrow cells of mice and decrease both the chromosomal aberrations(CA)andsister—chromatid exchange freqencies of splenocytes in mice induced by Cy;2.it could decreasethe activities of IL—6 like substance of splenocytes in mice induced by CY;3.there was a posi-tive correlation between IL—6 activities in the supernatant from cultured spleen cells and mi-cronucleus frequences in bone marrow cells or CA frequences in spleen cells.
