Suppression of T Cell Proliferation at Multiple Facets in the Cell Cycly by the Multiglycoside of Triperygium Wilfodii Hook F(T)
- VernacularTitle:雷公藤总甙在细胞周期多个阶段抑制T细胞增殖
- Author:
Liping ZHU
- Publication Type:Journal Article
- Keywords:
Triperygium Wilfodii Hood F.(T);
cell cycle;
flowcytometry
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
Human T cells can be induced to enter into G1(G1a and G1b)phase,but not into S and G2/M phases from G_0 phase by low—dose PHA(0.15?g/ml),and the low—dose PHA—activatedT cells can by induced to enter into S and G2/M phases by rIL—2.By using this system the ef-fect of the multiglycoside of Tryperygium Wilfodii Hood F.(T)on T cell proliferation has beenflowcytometrically analyzed.The data indicate that T inhibites T cell proliferation at the facetsG_0—G1a,G1a—G1b,G1—S and S-G2/M in the cell cycle.
