Cross—linking Membranous CD23 Molecules on B Lymphocytes Affect Its Proliferation and Second Messenger
- VernacularTitle:交联膜CD23分子对B淋巴细胞增殖及细胞内第二信使物质的影响
- Author:
Xuezhong YU
- Publication Type:Journal Article
- Keywords:
CD23 molecule;
B lymphocyte;
Cross—linkes;
Proliferation;
Second messenger
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
The possible roles of CD23 molecule on B cells were analyzed through cross—linking CD23 molecules on tonsillar B lymphocytes with CD23 natural ligands IgE and anti—CD23 McAb.After cross—linking CD23 molecules on activated B cells,the change of B cell proliferation and second messengers were observed.The results showed:(1)Double—valence anti—CD23 McAb and multi—valence IgE immune complex(IgEIC)had a two—way effect on B cellsproliferation,on high concentrations,they inhibited the proliferation of a etivated B cells by sAo In con trast with a certain lower concentration,they promoted the proliferation of activted B cells.The two—way effect depended on IL—4 which functions to up—regulate CD23;(2)mono —valence IgE had no observeable effects on B cells proliferation;(3)IgEIC and antl—CD23 McAb at the same concentration as stimulating B cell proliferation increased the intracellularCAMP levls,but not cGMP levels.(4)Anti—CD23 McAb provoked the transent increase of in tracellular free(Ca~(2+)).
