ULTRASTRUCTURAL CHANGES OF ENDOMYOCARDIAL BIOPSY FROM PATIENTS WITH LATENT KESHAN DISEASE
- VernacularTitle:潜在型克山病患者心内膜心肌活检的亚微结构改变
- Author:
Tiande HE
;
Jindian CHEN
;
Jichuan SUN
- Publication Type:Journal Article
- Keywords:
latent Keshan disease;
endomyocardial biopsy;
ultrastructure;
membrane permeability
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Twelve patients with latent Keshan disease in Xunyi County,Shaanxi Province were electron-microscopically observed with endomyocardial biopsy. Seven of them were males, 5 females; their ages ranged from 14 to 40 years old. They had suffered from the disease for 4 to 5 years in an average. The samples taken from their heart ventricles were prepared in routine,some were prepared with the modified lanthanum preparation according to Hoffstein's method to study the membrane permeability of the patients' myocardium at the same time,In almost all the samples, most of sarcoplasmic reticula,transverse tubule system and intercalated disc spaces are dilated. In some samples prepared with the lanthanum preparation, the electronic density particles are found in the intercalated disc spaces and scarcely in the cytoplasm of myocardium. Mitochondria often show changes both of proliferation and of degeneration simutaneously. Sometimes, minimal myolytic changes of filaments also can be seen, but there are no any necrotic or myolytic foci of myocardium found in the samples at all. Some nuclei are enlarged and twised,in them some pseudoinclusions also can be occasionally seen. Myofibrils vary their thickness. At the same time, they also have some abnormal branches. More than normal amount of fat droplets and glycogen granules deposite in the myocardial cells. Besides,there are lots of lipofusicin granules accumulated around the nuclei in the cytoplasm.
