THE EFFECT OF POLYACTIA B ON TUMOR-INFILTRATING IMMUNOCOMPETENT CELLS WITIHN MURINE S_(180) SARCOMA
- VernacularTitle:多抗乙素对小鼠S_(180)肉瘤中免疫活性细胞浸润的影响
- Author:
Changfu XU
;
Lusheng SI
;
Liang FANG
- Publication Type:Journal Article
- Keywords:
S_(180) sarcoma;
L_3T_4~+ cell;
Lyt_2~+ cell;
tumor necrosis factor (TNF);
polyaction B (Pb)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Polyactin B (Pb) has been proved to have the effect of considerable tumor suppression. Recently,we used murine S_(180) Sarcoma as a model and observed the effect of Pb on the tumor—infiltrating immunocompetent cells, and also the infiltrating neutrophils and the alteration of small blood vessels within the tumor tissue. Compared with control: in Pb—treated group, there were more L_3T_4~+and Lyt_2~+ lymphocytes infiltrating in the periphery of the tumor ,and also within the tumor. In addition, the tumors had more prominant hyperemia, micro—thrombosis and neutrophil infiltration around the necrotic areas. The present findings suggest that the tumor—suppression effect of Pb might be mediated through TNF produced by immunocompetent cells.
