CLINICAL STUDY ON Ca~(2+)-Mg~(2+)-ATP ENZYME ACTIVITY IN RED CELL MEMBRANES OF DIABETIC PATIENTS
- VernacularTitle:糖尿病患者红细胞膜钙 镁离子-三磷酸腺苷酶的研究
- Author:
Xinping LU
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus Erythrocyte membrane Ca2+-Mg2+-ATPase Hyperglycemia
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
The basal and calmodulin stimulated Ca2+-Mg2+-ATPase activities in erythrocyte membranes were measured in 40 diabetic patients and 36 normal subjects as control. The results showed that the enzyme activity is significantly decreased in diabetics. The reduction of enzyme activity is inversely related to serum glucose as well as glycosylated hemoglobin. It is suggested that the function of Ca2+-Mg2+-ATPase in red cell membrane of diabetics is decreased. This may be one of the factors causing diabetic microangiopathy. Furthermore, the reduction of enzyme activity might casually be related with hyperglycemia.
