ALTERATION OF RAT MYOCARDIAL PEPTIDE HORMONES WITH INCREASING AGE
- VernacularTitle:Wistar大鼠增龄过程中某些心源性肽类激素的变化
- Author:
Shaojun WEN
- Publication Type:Journal Article
- Keywords:
Angiotensin Atrial natriuretic peptide Myocardium
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
The process of aging can induce major alterations in structure and function of myocardium. 41 female Wistar rats-weighing 50-586 g were divided into 5 groups (1,3, 6,10, 21 mo.). The 21-month group was taken as aged rats. Myo-cardial homogenates (W/V= 1 g/10 ml) were prepared. The local myocardial immunoreactive Ang I, II and the ventricular ANF levels in different parts of the myocardium were measured by sensitive RIA. The sections of the myocardial tissue were prepared. The local Ang II and ANF were measured by immunohistochemistry. The results showed that auricular Ang II and ANF is markedly higher than the ventricular ones. Local myocardial Ang II is for the most part present in the cytoplasm. There is a positive correlation between the local Ang I and Ang II levels. There are significant differences in levels of Ang I, Ang II and interventricular septum ANF between various age groups. There is a perfect negait ve correlation between levels of Ang as well as ANF and the age in months. The reduction in local Ang II level is most striking in the 21-month group. The reduction of local Ang II level in the ventricles exceeds that in the atria. The experiment suggested that as age increases, some important hormonal functions of the heart gradually weaken; such a change is most noticeable in the ventricles.
