Immunosuppresive effect of the anti—activated mouse lymphocyte antigen monoclonal antibody(2H_3)on the allograft rejection and its mechanism
- VernacularTitle:抗激活小鼠T细胞抗原单抗抑制同种移植物排斥反应的作用及其机理
- Author:
Yongliang CHEN
;
Qiuzao HE
- Publication Type:Journal Article
- Keywords:
The Anti—Activated T Lymphoeyte Antigen McAb;
Allograft Rejection;
MLR;
CTL
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the mechanism of inducing a prolongation of allograft survival by immunizing the syngeneic mouse with activated murine spleen cells,we used an anti—activated mouse Tlymphocyte antigen monoclonal antibody(2H_3)made in our laboratory to examine the effect of 2H3on allograft survival in vivo and on cell—mediated immune rection in vitro.The results showed that 2H3 could significantly prolong the allograft survival in vivo and obviously inhibit the proliferation in MLR and CTL generation in bulk MLR as well as the T lymphocyte prolifer-ation to ConA in vitro.These data indicate that one of the mechanisms of the prolongation of al-lograft survival by immunizing the syngeneic mouse with activated murine spleencells may be due to the generation of an anti—activated mouse lymphocyte antigen antibodies in immunized ani-mals which can block process of allorection.
