STUDY ON THE ETIOLOGY OF CUSHING'S DISEASE BASED ON PLASMA CORTICOTROPHIN-RELEASING HORMONE-LIKE BIOACTIVITY AND EFFECTS OF NEUROTRANSMITTERS
- VernacularTitle:从血浆促肾上腺皮质素释放素样生物活性和神经递质类药物的作用探讨Cushing病病因
- Author:
Wei TONG
- Publication Type:Journal Article
- Keywords:
Cushing's disease Neurotransmitter CRH bioactivity
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
The plasma corticotrophin-releasing hormone-like bioactivity was measured in normal individuals, patients with Cushing's disease and other diseases of hypothalamic-pituitary-adrenal axis with the techniques of rat pituitary cell peri-tusion and AGTH radioimmunoassay. Combined with the response of the patients to neurotransmitter agonist and antagonist, it was hypothesized that most patients with Cushing's disease have a primary pituitary lesion and that hyper-tisolemia damaging hippocampus and weakening its inhibition on hypothalamic-pituitary-adrenal axis may have an important role in the pathogenesis.
