Preliminary study on the mechanism of cell adhesion activity of CEA
- VernacularTitle:癌胚抗原细胞粘附作用的机理研究
- Author:
Baohua XUE
- Publication Type:Journal Article
- Keywords:
CEA;
Cell adhesion;
Adhesion molecule;
Microfilament
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
Our previous experiment demonstrated that CEA is a cell adhesion molecule.The mechanism of cell adhesion activity of CEA was studied in this experiment using CEA positive cells line LoVo.Electron—micrographys study showed that LoVo cells adhered by cross contact of microvilli on the cell surface,and formation of gap junction and desomosomal junction were also observed.Cell adhesion activity of CEA was apperently influenced by emperature,NaN3,EDTA and cytochalasin B,showing that cell adhesion is an energy-consuming process depending on bivalent cation and movement of microfilament.A model of CEA on cell membrane was put forward.
