Detection of anti-F(ab')_2 antibody in patients with SLE and evaluation of its clinical significance
- VernacularTitle:SLE患者血清抗F(ab′)_2片段抗体的测定及其临床意义
- Author:
Zhongchen KOU
;
Xingmin ZHANG
- Publication Type:Journal Article
- Keywords:
SLE;
Anti-F(ab')_2Antibody;
anti-ds-DNA antibody;
E1ISA
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Anti-F(ab')_2 and anti-dsDNA-F(ab'):fragment(idiotype)Were prepared from digested normal human IgG and anti-dsDNA antibody with pepsin.Anti-F(ab')_2 antibody was determined by ELISA in 46 patients with SLE.A significant correlation between titers of anti-dsDNA-F(ab')_2 and anti-F(ab'):antibodies was observed.Results show high levels of anti-F(ab')_2 and low levels of anti-dsDNA antibodies in patients with remisson SLE activity.These findings suggest that the general IgG-F(ab')_2 antibodies and the anti-dsDNA-F(ab')_2 idiotypes in SLE sera may express some common structural epitopes.The measurement of anti-F(ab')_2 antibody levels may prove usefuladditional parameters assessing the clinical status.
