Biodistribution and radioirnmunoimaging of monoclonal antibody to human melanoma in tumor-bearing nude mice
- VernacularTitle:抗人黑色素瘤单克隆抗体在荷瘤裸鼠体内的分布及其定位显像
- Author:
Fang TIAN
;
Boquan JIN
- Publication Type:Journal Article
- Keywords:
Melanoma;
Monoclonal antibody;
Radioimmunoimaging;
Tumor-bearing nude mice
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Biodistribution and radioimmunoimaging of monoclonal antibody HB8759 agaist human melanoma in tumor-bearing nudemice were investigated.The results showed that mean tumor: nontumor(5 main organs)ratios were 6.6 and 9.6 at 48 and 72hr after injection of the ~(131)Ⅰ—McAb,respectively,and tumor was clearly visualized under ECF at the same time.It is suggested that McAb HB8759 is a potential biologic product for diagnosis of metastic melanoma and intraocularmelanoma and clinical treatment of melanoma.
