The immunoregulatory mechanisms of N-(2-Carboxyphenyl)-4-Chloroanthranilic Acid Disodium(CCA)on treating Adjuvant Arthritis(AA)in rats
- VernacularTitle:卡芬尼对大鼠佐剂性关节炎治疗作用的免疫机制
- Author:
Donglai MA
- Publication Type:Journal Article
- Keywords:
Carfenil;
Rat adjuvant arthritis;
Immunoregulation
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
We have studied the immunoregulatory mechanisms of CCA on treating AA rats.In vivo,the lower response of splenocytes to ConA and decreased T-suppressor cells in peripheral blood were restored to normal by CCA given orally,but the elevated IL-1 synthesis,H_2O_2 release of peritoneal macrophages(PM(?)s)and PGE_2 production of inflamed joints were reduced by it.In vitro,ConA-induced splenocytes proliferation were enhanced with 0.1-1?g/ml of CCA,but diminished with 10?g/ml of it.CCA(100?g/ml)had no effect on H_2O_2 release of PM(?)s from normal rats,but it could reduce the H_2O_2 release from AA rats.In ummary,the therapeutic effect of CCA on AA rats were dependent on the original immune state of the rats and doses of CCA administerd.
