BIOAVAILABILITY OF SELENIUM IN SELENIUM-YEAST TO YOUNG RESIDENTS IN A KESHAN DISEASE AREA
- VernacularTitle:克山病病区青少年对硒酵母硒的生物利用率
- Author:
Hongbin SONG
;
Guanglu XU
;
Wenlan XUE
- Publication Type:Journal Article
- Keywords:
Sclcnium-yeast;
sodium selenite;
bioavailability, glutathione peroxidase;
selenium;
Keshan disease
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract To evaluate the bioavailability of selenium (Se) in Se-yeast to residents with low-Se status, fifty-two youth in a Keshan disease area were randomly divided into three groups, and they were given orally 200 ?g Se daily as So-yeast or sodium selenite, or ordinary yeast for 12 weeks, respectively. Se contents and activities of glutathione peroxidase (GSHpx) in blood were measured at wk 4 and 8 of supplements and 8wk alter the supplements were discontinued. The results show that: 1. the retention of Se in either plasma or erythrocyte is sigificantly higher in Se-yeast than in sodiurn selenite; 2 the effect of Se in Se-yeast is superior to that of sodium selenite for maintaining GSHpx activities; and 3. the relative bioavailabilities of Se in Se-yeast are 556% and 178% when using erythrocyte and plasma Se contents as the response critria, as well as 158% and 116% when estimated by platelet and plasma GSHpx activities. The results indicate that the bioavailability of Se to the residents in a low-Se Keshan disease area is greater when supplemented Se-yeast than selenite.
