PROTECTION OF ADRIAMYCIN-INDUCED SUBACUTE CARDIOMYOPATHY IN MOUSE BY SELENIUM PRETREATMENT
- VernacularTitle:硒对小鼠亚急性阿霉素心肌损害的保护作用
- Author:
Xing CHENG
;
Guanglu XU
;
Wenlan XUE
- Publication Type:Journal Article
- Keywords:
adriamycin;
cardiomyopathy,mouse;
selenium;
protection
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The protective effect of selenium (So) on the subacute cardiomyopathy was investigated in the mouse given a single dose of adriamycin (ADR 17. 5mg/kg ip). Se pretreatment (80?g/kg?10 ip) produced protection against the ADR-induced early myocardial damage associated with increased permcability of cell membranes as evidenced by apparent D- PAS (diastase- periodic acid-Schiff) staining material noted in the sarcolemma. The protective effect of Se could be partially explained as the detoxication of lipid peroxides via the action of enhanced cardiac Se-glutathione peroxidase.
