Immunoregulation effect of supernatants from JM cell culture(SPN_(JM))on proliferation of human B lymphocytes and mouse spleen cells
- VernacularTitle:JM 细胞培养上清对人 B 淋巴细胞和小鼠脾细胞增殖的免疫调节作用
- Author:
Hui XU
- Publication Type:Journal Article
- Keywords:
Cytokine;
Lymphocyte;
Immunoregulation;
Acute lymphocytic leukemia
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
JM is a acute lymphocytic leukemia cell line derived from immature T lymphocytes in human thymus.We bserved the immunoregulation effect of supernatants from JM cell culture(SPN_(JM))onproliferation of human B ymphocytes and mouse spleen cells by using purified human B lymphocytesand mouse spleen cells stimulated with AC.It is showed that SPN_(JM),which suppresses T lymphocyteproliferation,enhance the proliferation response of uman B cell and mouse spleen cells stimulatedwith SAC.Without inducement of SAC,SPN_(JM) with HrIL-2 still nhances B lympohocyteproliferation.Additionally,SPN_(JM) is able to up regulate T cell proliferation response at lowconcentration(1:640)although it suppresses T cell proliferation at high concentration.
