Studies on the anti-idiotypic antibodies against anti-HBs
- VernacularTitle:乙型肝炎表面抗体的抗独特型研究
- Author:
Lijun GUO
- Publication Type:Journal Article
- Keywords:
Anti-idiotypic antibody;
Anti-HBs;
Monoclonal antibody
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Hightiter anti-idiotypic antibodies(Ab_2)sera and two monoclonal anti-idiotypic antibodies (McAb_2)were repared by immunizating syngeneic BALB/c mice wth a complex of 7A_4 monoclonalantibody(McAb_1)against the a eterminant of the Hepatitis B Surface antiger(HBsAg)。Both Ab_2sera and McAb_2 recognize the idiotype of aratope n 7A_4McAb_1.Ab_2 sera contain the antibodiesbinding specially to anti-HBs from other species(guinea pig、onkey、rabbit and goat)and the twoMcAb_2 can not bind to these anti-HBs.Therefore it is thought that the two McAb_ re noninternalimage(Ab_2?)anti-idiotypic antibodies,this study proves that the McAb_1 against he eterminantof the HBsAg are different in their paratope,The McAb_2 can be used to stinguish the parotope onthe McAb_1 as a biological probe.
