Study on the associations between HLA antigens and Mixed Connective Tissue Disease(MCTD)
- VernacularTitle:混合性结缔组织病与 HLA 抗原的相关性
- Author:
Nan SHEN
- Publication Type:Journal Article
- Keywords:
HLA;
MCTD;
U_1SnRNP
- From:
Chinese Journal of Immunology
1985;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In this report,We performed HLA-A、—B and DR antigens typing and detected antibodies to U_1RNP ploypeptide antigen by Immunblotting in 37 patients with MCTD.The results showed that (1)there were no significant differences between the MCTD patients and normal controls in the frequencies of HLA—A,—B antigens.(2)there were significant differences between patients fulfilling sharp's criteria and normal controls in the frequencies of DR4 and R5 (60.9%,RR=4.7,Pc0.05).(3)the frequencies of DR4 and R5 in MCTD patients with myositis were increasedcompared with these without myositis(P0.05).
