An Experimental Study of High Dose of Glucocorticosteroid in Treatment of Traumatic Brain Edema in Rats
- VernacularTitle:大剂量糖皮质激素防治创伤性脑水肿的实验研究
- Author:
Cheng ZHU
- Publication Type:Journal Article
- Keywords:
brain edema head injury glucocorticosteroid
- From:
Chinese Journal of Trauma
1991;0(S1):-
- CountryChina
- Language:Chinese
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Abstract:
In order to provide an experimental evidence for clinical utility, we undertook a series of experimental studies of glucocorticosteroid to treat closed head injury and gun shot brain wound, For studies of closed injury in rats, there were four groups as follows: Group 1: methyl prednisone 30mg/kg (MPG); Group 2: dexamethasone 5 mg/kg (HDMG): Group 3: dexamethasone0.5mg/kg (LDMG); and Group 4: normal saline as a control group (CG) For study of gun shot wound of brain, The dogs were divided into three groups, Grup 1 (wound group, n=8); Group 2 (treated group, n=7) and group 3 (control group, n=7). After injury, the vital signs were observed, the water content of the brain and Even' s blue level were measured and the brain were examined under optical and electronic microscopy, All results proved that secondary traumatic edema in the animals used high dose glucocotricosteroid were much more slight
