Primary study on pathogenesis of Immunoglobulin G subclass deficiency
- VernacularTitle:免疫球蛋白G亚类缺陷病发病机理的初步研究
- Author:
Jian SUN
- Publication Type:Journal Article
- Keywords:
Immunoglobulin G subclasses;
Immunodeficiency;
Interleukin-6;
B cell differentiaion factors
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Measurement of IgG subclass productions, activities of interleukin-6 (IL-6) and B cell differentia- tion faotors (BCDFs) in vitro were carried out on 37 children with IgG subclass deficiency. The frequency of defective IgG subclass productions induced by PWM is in order asfollows: IgG (7/9), IgG4 (6/11), IgGl (9/17) and IgG3 (2/13). Decreased CD4 oells from PBL, low leves of lymphocyte proliferative responses to PHA and SAC, and reduced activities of IL-6 and BCDFs were found in IgG subclass deficiency patinets. 12 out of 15 cases who had decreased IgG subclass production associated with a reduced activities of IL-6 or/and BCDFs; only 4 out of 15 cases who had normal amounts of IgG subclass production associated with such lymphokine defects. The results would suggest that IgG subclass deficiency may be related to the aberration of isotype switch in order along Ig heavy chain constant gene from 5' -3', and that a variety of abnormalities in T and B cell functions share the contribution to the pathogenesis of IgG subclass deficiency, in which T cell dysfunction may play a more important role.
