The effects of substance K and substance P on lymphocytes of spleen and thymus in mice
- VernacularTitle:神经肽K物质、P物质对小鼠脾脏和胸腺淋巴细胞的影响
- Author:
Qiang TONG
;
Xirui GE
- Publication Type:Journal Article
- Keywords:
Substance K;
Substance P;
Immunomodulation function of neuropeptide;
Lymphocyte proliferation;
Antibody production;
T lymphocyte subsets
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
effects of tachykinin SK, SP on mouse splenocyte and thymocyte have been studied.It was found that SK and SP can stimulate ConA or LPS-induced splenocyte prolifertion and antibody production (in cluding IgG, IgM, IgA).5 ?10~(-7)M/L SK can stimulate ConA-induced thymocyte proliferation but SP can't. The subsets of T lymphocytes in spleen and thymus have been changed after SK treatment by FACS analysis. These results show that SK and SP may play a significant regulatory role in immune response.
