Study of Anti-CD9, CD10 immunotoxins to kill leukemiccell and the effect, on hemopoiesis
- VernacularTitle:CD9、CD10单克隆抗体免疫毒素对白血病细胞的清除率及对造血细胞的影响
- Author:
Yan LI
- Publication Type:Journal Article
- Keywords:
Immunotoxin;
Leukemic cell;
Hemopoietic cell
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
Immunotoxin consists of the antibody, which can specifically recognize relative antigen on the surface of leukemic cell, and intact ricin, which kill cell. It is very profitable to eliminate leukemic cell from bone marrow for prophylaxis of leukemia relapse after bone marrow transplantation. In the study, we reported that clongoenic leukemic cell (Nalm-6) were eliminated by two different immunotoxins (with CD9 and CD10). The inhibiting effect of immunotoxins in useful dose on the proliferation of hemopoietic progenitor cells (CFU-mix, BFU-E and CFU-GM) was not obviously.It is probably that immunotoxins will be used in autologous bone marrow transplation.
