Enhancing effect of tumor necrosis factor (TNF) on the in vitro and in vivo antitumor activity of LAK cells
- VernacularTitle:基因重组肿瘤坏死因子对LAK细胞体内外抗肿瘤作用的增强效果
- Author:
Xuetao CAO
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor;
Interleukin-2;
LAK cells;
Immunotherapy of cancer
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
Although TNF alone was not capable of inducing LAK activity and could not enhance the LAK activity induced by IL-2 at optimal concentration (1000U/ml), TNF (500U/ml) was found to act synergistically with IL-2 at suboptimal concentration (10～100U/ml). This TNF/IL-2 synergistic effect was blocked by anti-TNF McAb (Z8) or anti-IL-2R? chain McAb (TU27). When TNF and IL-2/LAK cells were combined to treat tumor-bearing mice,TNF could potentiate significantly the therapeutic effect of IL-2/LAK cells in vivo.
