Enhancing effects of Ginsenosides on cellular Immune function via Hippocampus and its possible mechanism
- VernacularTitle:人参皂甙通过海马介导的细胞免疫增强效应及可能机制
- Author:
Ruiqiong WU
;
Guizhen YANG
- Publication Type:Journal Article
- Keywords:
Ginsenosides
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was expected to elucidate the possible mechanism of enhancing effects of Ginsenosides (GS) on immune function via hippocampus (HC). Our main results indicate that after the injection of GS into rat bilateral HC directly by condiuts with dose of 50 ?g/day for 4 days, thymocyte proliferative response to Con A and NK activity were increased significantly as compared with those of control groups. Furthemore, it has been found that this elevation coincides with decreased plasma ACTH and corticosterone level in the experimental group. Besides these, GS also can augment the thymocyte proliferating factor in the culture supernatant of HC slices. The data described above suggests that the action of GS induced cellular immunity appears to occur in part of neuroendocrine system by suppression pituitary-adrenal axis or of the promoting factor of HC.
