THE LONG-TERM OBSERVATION ON TRANSPLANTATION OF ENCAPSULATED RAT ISLETS INTO DIABETIC MICE
- VernacularTitle:糖尿病小鼠腹腔内移植免疫隔离膜包裹大鼠胰岛长期疗效的观察
- Author:
Changda SHU
;
Jundept HE
- Publication Type:Journal Article
- Keywords:
Immuno-isolated membrane Xenotransplantation of islets of Langerhans
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Rat islets encapsulated in the immuno-isolated membrane were transplanted intraperitpneally into eleven streptozoto-cin induced diabetic mice. The effective rate was 91% while all were rejected in the non-encapsulated xenograft group. Four mice showed complete remission, and the longest normoglycemic period in those mice was 360 days. The pathological changes of islets in the long-term successful xenograft group were studied and atrophy was found. It proved that the immuno-isolated membrane can resist rejection during xenotransplantation.
