Interleukin-2 and its receptor abnormalities in Ankylosing Spondylitis and Rheumatoid Arthritis
- VernacularTitle:强直性脊柱炎及类风湿关节炎患者IL-2及IL-2受体测定
- Author:
Feng HUANG
- Publication Type:Journal Article
- Keywords:
Ankylosing Spondylitis;
Rheumatoid Arthritis;
IL-2;
IL-2 receptor;
Flow Cytometry
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The production of IL-2 by peripheral blood lymphocytes from patients with Ankylosing Spondylitis (AS)and Rheumatoid Arthritis (RA) was compared with that of healthy controls. Patients with AS and RA showed a significant overproduction of IL-2.Membrane-bound IL-2 receptor was recognized by monoclonal anti-Tac antibody by using a flow cytometry. There was a marked increase of IL-2 receptor in patients with RA, while the level of IL-2 receptor in patients with AS was comparable to that of normal controls. The results suggested that there was obvious abnormalities of membrane-bound IL-2 receptor expressing and production of IL-2 in patients with AS and.RA which may contribute to the pathogenesis of these diseases.
