THE CHANGES OF LDL RECEPTOR AND ENDOCRINE FUNCTION IN NON-FAMILIAL HYPERCHOLESTEROLEMIA
- VernacularTitle:高胆固醇血症的生化机理——非家族性高胆固醇血症患者LDL受体和内分泌功能的变化
- Author:
Bingyi SHI
- Publication Type:Journal Article
- Keywords:
Non-familial hypercholesterolemia Low-density lipoprotein receptor
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
The low-density lipoprotein (LDL) receptor level and endocrine function were studied in 30 cases of non-familial hypercholesterolemia. The results showed that endocrine dysfunction may play a role in the pathogenesis of hyper-cholesterolemia, for example, the elevation of insulin and growth hormone level, the abnormal ratio of estrogen and testosterone. In addition, the increase of TXB2 and 6-ketone prostacyclihe may make the blood hypercoagulative, raise the incidence of myocardial infarction and cerebral thrombosis. Except the physiologic compensation the LDL receptor level in non-familial hypercholesterolemia may also be regulated by insulin and estrogen.
