Study on the mechanism of autoimmunity induced by CJ-S131 infection
- VernacularTitle:空肠弯曲菌慢性感染诱致自身免疫反应的机理初探
- Author:
Bing SUN
;
Baoli MA
- Publication Type:Journal Article
- Keywords:
Campylobacter jejuni;
Chronic infection;
Auto-ant i bodies;
Autoimmunity;
T suppressor cell
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Using Campylobacter ieiuni, strain of CJ-S131 to infect KM mice. Three months after infection, we examined the function of T and B cells in infected mice. We found that(l) there were higher, level antibodies against ds-DNA, ss-DNA.(2) ConAinduced suppressor cell activity was decreased and the ratio of Th/Ts was increased (3) The formation of PFC and lymphocyte transformation induced by LPS.PHA and ConA were increased. (4) The DTH reaction also was increased. The results mentioned above indicated that chronic infection of CJ-S131 would induce autoimmunity in KM mice.The ineffitiency of Ts cell function could be related to the hyperactivity of Th and B cells.
