AN ANTl-TSH ANTI-IDIOTYPIC ANTISERUM WITH ACTIVITY OF THYROID-STIMULATING INHIBITOR IMMUNOGLOBULIN (TSH)
- VernacularTitle:抑制型抗TSH抗独特型抗体的发现及其意义
- Author:
Ning FU
- Publication Type:Journal Article
- Keywords:
Anti-TSH anti-idiotype TSH-binding inhibitor immunoglobulin (TBII) Thyroid-stimulating inhibitor immunoglobulin (TSII)
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Rabbit anti-TSH anti-idiotypic antiscra were raised by immunization with auti-TSH antibody. The antiserum from rabbit No. 551 was found to have the activity of inhibiting the binding of TSH receptor on thyroid cell membrane and 125I-TSH, that is, TBII (TSH-binding inhibitor immunoglobulin) positive. This antiserum was also shown to inhibit cAMP release stimulated by 100 mU/L bTSH. The characteristics of No. 551 antiserum were similar to of patients with myxedema.
