THE EFFECT OF TOTAL FLAVONES OF HIPPOPHAE RHAMNOIDES L. ON BEATING AND ELECTRICAL ACTIVITY OF CULTURED CARDIAC CELL
- VernacularTitle:沙棘总黄酮对培养心肌细胞搏动及电活动的影响
- Author:
Jie WU
;
Xiaoguang LI
- Publication Type:Journal Article
- Keywords:
TFH;
culturcd card ac cell;
action potential;
cellular beating
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
In this paper, we studied the effect of total flavones of Hippophae rhamnoides L (TFH) on beating and transmembrane potential of cultured sucking rat cardiac cell. The results indicated that cellular beating rate and beating amplitude were significantly reduced, the action potential duration of 50% and 90% repolarization was sbortened, the slope of phase 4 depolarization was decreased, and other parameters of the action potential showed no significant change. In addition, we also observed that TFH could make the spontaneous abnormal beating of cell change into regular beating. These findings suggested that the mechanism of TFH on cultured cardiac cell might have some relation to antagonizing inward flow of Ca~(2+) and aocelerating the move of k' outward.
