THE EFFECTS OF SUPEROXIDE DISMUTASE ON MYOCARDIAL MITOCHONDRIA INJURED BY REOXYGENATED PERFUSION
- VernacularTitle:超氧化物歧化酶对心肌线粒体再给氧损伤的作用
- Author:
Tiansheng SHEN
;
Jisheng YANG
;
Junhong WANG
- Publication Type:Journal Article
- Keywords:
myocardial mitochondria;
reperfusion injury;
mitochondrial spiration;
succinic dehydrogenase
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of superoxide dismutase (SOD) on mitochondrial function after hypoxic and reoxygenated perfusions in isolated rat hearts were observed. Significant decreases in respiration control ratio (RCR) and ADP/O ratio (P/O) as well as activities of succinic dehydrogenase (SDH) and cytochrome oxidase (CCO) were found alter 40 minutes' hypoxia and 20 minutes' reoxygenated perfusion. Adding SOD to the perfusion fluid during the reperfusion period could restore the decreased mitochondfial function, which was shown by increased RCR and P/O as well as activities of SDH and CCO.
