Experimental study of antitumor of spleen LAK cell and LAK-88/DC cell (?)ne from 615 Inbred mice
- VernacularTitle:615系小鼠脾LAK细胞及LAK一88/DC细胞系抗癌作用的实验研究
- Author:
Pei YU
- Publication Type:Journal Article
- Keywords:
LAK cell;
LAK-88/DC cell line;
Adoptive immunotherapy;
L615 murine leukemia
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present experiment, we investigated the im munoprophylactic and immunotherapeutic effects of transferring spleen LAK cells or " LAK-88/DC " cells from 615 inbred mice against mouse leukemia. The results showed that transferring LAK cells or "LAK-88/DC" cells and injecting conditional medium for a week 21 days before L615 inoculation induced significant prophylactic effects, which cured 80% of the L615-sufferring mice. Injecting conditional medium alone was also effective, which cured 60% of the mice, While transferring LAK cells or "LAK-88/DC" cells at the same time with L615 inoculation or 1 day after L615 inoculation presented no apparent therapeutic effect. However, when combined with cyclophosphamide (CY) chemotherapy, the transfer of LAK cells or "LAK-88/DC " cells 5 days after L615 inoculation could prolong the mean survival time and even cured 25%-28.6% of the advanced L615 leukemic mice.
