CALCIUM ANTAGONISTIC EFFECT OF dl-TETRAHYDROPALMATINE ON ISOLATED RAT UTERUS
- VernacularTitle:dl—四氢巴马汀在子宫平滑肌上的钙拮抗作用
- Author:
Dongke ZHAO
- Publication Type:Journal Article
- Keywords:
tetrahydropalmatine;
calcium channel blockers;
uterus;
potassium chloride;
oxytocin
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The calcium antagonistic effect of dl-tetrahydropalmatine(THP) on isolated rat uterus was observed. THP decreased significantly uterine contraction induced by oxytocin, KCl, CaCl_2. THP nonparallelly shifted cacium chloride dose-response curve to the right, and decreased the maximal response, showing noncompetitive antagonism, PD'_2 value was 4.6. THP obviously decreased the intracellular and extracellular calcium-dependent components in oxytocin-induced contraction response. These results have shown that THP not only mainly inhibited potential dependent calcium channel, but also decreased calcium relesese from intracellular stores.
