Co-expression of two HTC-defined HLA-D specific Dw 3 and Dw 7 c in DR 7 positive halotype among the Shanghai Chinese
- VernacularTitle:上海人群中HLA-DR7单倍型同时表达两种纯合分型细胞检出的特异性Dw7c及Dw3
- Author:
Guangyan ZHOU
- Publication Type:Journal Article
- Keywords:
HLA Cellular Typing with HTCs;
Halotype;
HLA-D Triplet
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
When 56 unrelated subjects in Shanghai were typed for HLA-A, B, C, D, DR and DQ with the homozygous typing cells (HTCs) and sera of 3 rd Asia-Oceania Histocompatib(?)l(?)tv Workshop Conference, only five of the eleven Dw 3 positive subjects were identified to be associated with the correspondingly designated DR 3. For the other six subjects, Dw 3 were co-expressed with Dw 7 c (Dw7+Dw17) and DR7 in the same halotype, resulting in a Dw "triplet" when the third D specificity was detected in the other halotypes. The Dw 3 was thus divided into two forms characterized by the two different haplotypes in which it was involved: HLA-B17-DR 3-DRw52-Dw3 and HLA-B13-DR 7-DR w53-DQ w2-Dw7 c-Dw3. With circumstancial evidences, the co-expression of Dw 3 and Dw 7 c was attributable to a tentative DQw 2 split in Chinese, which, as a part of the antigen epitopes, might take part In the expression of Dw3 and Dw7 c specificities and could be recognized by the HTCs.
