Imbalance of T cell subpopulations in immunologic pathogenesis of throm boangiitis obliterans
- VernacularTitle:T细胞亚群比例失调在血栓闭塞性脉管炎发病机制中的作用
- Author:
Dajun SUN
- Publication Type:Journal Article
- Keywords:
T Cell Subpopulation;
Antiartierial Antibody;
Circulating Immune Complex;
Immunologic Pathogenesis;
Thromboangiitis Obliterans
- From:
Chinese Journal of Immunology
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
The T cell subpopulations of peripheral blood from 60 TAO patients and 40 normal subjects were detected with 3 kinds of monoclonal antibodies using indirect immunofluoresence technique. Meanwhile, the antiarterial antibodies (AAA) and circulating immune complex (CIC) from the sera of above patients and normal subjects were also determined. The results of the experiment suggests: (1) The functional disorders of immunoreguiating T cell (T4~+, T8~+),especially the severe decrease of T8~+ cell percentage play an important role in the pathogenesis of TAO;(2) The imbalance of T cell subpopulations have close relation to the production of antiarterial antibodies.
