METHIONINE-ENKEPHALIN ALTERATION OF MITOGENIC AND MIXED LYMPHOCYTE CULTURE RESPONSES IN ZINC-DEFICIENT MICE
- VernacularTitle:蛋氨酸—脑啡肽改变缺锌小鼠脾淋巴细胞的增殖反应
- Author:
Gang LI
- Publication Type:Journal Article
- Keywords:
methionine enkephalin;
zinc deficiency;
lymphocytes;
mitogens;
cultured cells
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of methionine-enkephalin (M-EnK) on mitogenic and mixed lymphocyte culture (MLC) proliferation of splenocytes from Zn-deficient, restricted and control mice were evaluated. The data from this experiment showed that M-Enk could suppress the responses of splenocyte from th 3 groups to eoncanavalin A(Con A), but less inhibition was observed in the Zn-deficient group. M-Enk could also enhance the responses to Pokeweed Mitogen (PWM) and decrease the response to Lipopolysaceharide (LPS) in all groups. Alteration of proliferative responses to LPS,Con A and FWM was reversible in the presence of 10 ?mol/L naloxone, indicating that the effect of M-Enk on cellular proliferation was mediated by the opioid receptor. In the proliferation of MLC, the response of lymphocytes from Zndeficient mice was increased in the absence of M-Enk and M-Enk could suppress this increased response. It is therefore concluded that Met-Enk can modify the pattern of mitogenic responses and the alteration in Con A and MLC responses can be influenced by zinc deficiency.
