GROWTH INHIBITION OF ERYTHROID COLONIES BY AUTOLOGOUS SERA AND THE CLINICAL EFFECT OF ERYTHROPOIETIN IN CHRONIC RENAL FAILURE
- VernacularTitle:慢性肾功能衰竭患者血清对红系祖细胞的抑制及红细胞生成刺激素的疗效
- Author:
Jinyuan WANG
- Publication Type:Journal Article
- Keywords:
chronic renal failure;
serum inhibitor of CFU-E;
erythoproietin
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
We investigated the inhibitory effect of autologous sera on erythroid colony forimation(CFU-E) of bone marrow cells from patients with chronic renal failure and the clinical effect of recombinant erythropoietin, Colonies formed in cultures using autologous serum(AS) decreased in 15 cases as compared with those using fetal calf serum(FCS). This inhibitory effect of autologous sera was diminished by treatment with activated charcol in all these cases. The degree of hemoglobin increase after administration of recombinant erythropoietin appeared to correlate with the intensity of inhibitory activity of AS, These data indicate the clinical significance of an inhibitor(S) of erythropoiesis in uremic sera and suggest that the clinical effects of erythropoietin in this disease are further improved if the inhibitor(s) can be effectively removed.
