STUDY ON GALLSTONE FORMATION INDUCED BY DIETS AND PREVENTED BY ASCORBIC ACID IN GUINEA PIGS
- VernacularTitle:饮食诱发豚鼠胆结石及维生素C防止结石形成的实验研究
- Author:
Bin REN
- Publication Type:Journal Article
- Keywords:
gallstone;
lithogenic diet;
ascorbic acids;
prevention;
guinea pig;
bile acid
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Two different diets(high cholesterol and low protein) were used to induce gallstone formation in guinea pigs. After the guinea pigs had been fed on lithogenie diets for 8 weeks, the rate of gallstone formation was 100% in both groups. However, when ascorbic acid was added in the diets, the rate of gallstone formation was reduced to 16.7% and 52,9% respectively. The mechanism of gallstone formation was explored through observing the effect of animals diet change on gallstone formation and the effect of ascorbic acid on gallstone prevention. At the same time, the micro-structure observation and the component analysis of gallstone, the change of ultrastructure of the liver and gallbladder, and the quantitative analysis of conjugated bile acids of biles were condueted.
