Mechanism of the immunodeficiency of the allogeneic bone marrow transplantation mice
- VernacularTitle:异基因骨髓移植小鼠免疫功能缺损机制的探讨
- Author:
Shusheng XIE
- Publication Type:Journal Article
- Keywords:
Allogeneic bone marrow transplantation;
T suppressor cell;
Immunodeficiency;
Graft-versus-host disease
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
In this report we studied the mechanism of the immunodeficiency of the recipients grafted with allogeneic bone marrow. The results indicated that the IL-2 production of ABMT mice was seriously impaired. Further investigation revealed that the spleen cells of ABMT mice were able to suppress GVHD in the lethally irradiated BALB/c mice. After removing the T cells, the spleen cells of ABMT mice lost this inhibitory effect. Furthermore, the supernatant of the spleen cell culture of ABMT mice is able to inhibit the mixed lymphocyte reaction, the IL-2 production and the killing activity of the CTL of normal BALB/c mice. After removal of T cells, the supernatant of the spleen cell culture lost its inhibitory effect. These results suggested that the increased activity of T suppressor secreting a non-specific suppressor factor might be an important mechanism of the immunodeficiency of ABMT mice.
