Immunoreactive angiotensin II (irAII) translated by lymphocyte mRNA from spontaneously hypertensive rats (SHR) and T lymphosarcoma cells in vitro
- VernacularTitle:自发性高血压大鼠淋巴细胞及T淋巴瘤细胞mRNA体外转译血管紧张素Ⅱ样物质
- Author:
Dongji ZHANG
;
Guizhen YANG
- Publication Type:Journal Article
- Keywords:
Immune angiotensin Ⅱ;
Translation;
Lymphocyte mRNA;
Spontaneously hypertensive rat;
T lymphosarcoma cell
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
irAII was translated by SHR and WKA rat spleen lymphocyte and thymocyte RNA in wheat germ free synthesizing system. The translation efficency of irAII at the most proper concentration of SHR immune cell RNA is higher than that of WKA rat immune cell RNA. the result also showed that irAII translation was increased in the rat spleen lymphocytes stimulated by concanavalin A (ConA). Furthermore, irAII, irAI and renin-like were translated by MLA-144 cell (T lymphosarcoma cell) poly (A) RNA in cell free translation system from wheat germ. The results proved that the immune cells of rats produce irAII in a constitutive or inducible fashion for the first time.
