Comparison of in vitro and in vivo antitumor activity between tumor—infiltrating lymphocytes (TIL) and LAK cells
- VernacularTitle:IL—2激活的肿瘤浸润性淋巴细胞与LAK细胞体内外抗肿瘤作用的比较
- Author:
Xuetao CAO
- Publication Type:Journal Article
- Keywords:
Tumor-infiltrating lymphocyte;
Interleukin-2;
Lymphokine-activated killer cells;
Adoptive immunotherapy;
Cytotoxicity
- From:
Chinese Journal of Immunology
1985;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
It was demonstrated that TILs exhibited higher cytotoxicity to autologous tumor cells than that of LAK cells grown under identical conditions, and TILs had target cell specificity.The cytotoxicity of TILs to other tumor cells was lower than that of LAK cells, and TILs had no cytotoxicity to ConA-induced lymphoblast cells but LAK cells did have some cytotoxicity to the normal cells. The cytotoxicity of TILs to B 16 melanoma cells was reduced by monoclonal antimelanoma antibodies (M2590 and M562) which can block the activity of antimelanoma CTL, suggesting TILs contained high level of CTL activity. TILs were found to be more effective in their therapeutic potency in vivo on a percell basis than were LAK cells. These results indicate that TILs are more suitable to the adoptive immunotherapy of turn or as effector cells than LAK cells.
