THE NEGATIVE FEEDBACK REGULATION OF PITUITARY N-POMC SECRETION BY GLUCO CORTICOIDS WAS BLUNTED IN CUSHING'S DISEASE
- VernacularTitle:柯兴病患者N-POMC分泌对糖皮质激素负反馈调节的反应变迟钝
- Author:
Zhaolin LU
- Publication Type:Journal Article
- Keywords:
Glucocorticoid Cushing's disease Negative feedback regulation N-POMC
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effect of hydrocortisone (135 nag i.v. as a bolus) on the levels of serum N-POMC was studied in the patients with Cushing's disease [including three groups: untreated (CD, n=8), post-adrenolectomy without Nelson's syndrome (CDA, n=5), and Nelson's syndrome (NS, n=4)]; Addison's disease (AD, n = 13) and congenital adrenal hyperplasia (CAH, n=4). The results showed that the levels of serum N-POMC were decreased after the administration of hydrocortisone in all three groups of Cushing's disease, however the suppression rate of N-POMC was much lower in these groups than that in AD and CAH (P
