Transforming growth factor ? inhibits the cytokine-mediated induction of cytotoxic T cell from murine thymus.
- VernacularTitle:转化生长因子—?对淋巴因子诱导胸腺细胞CTL分化的抑制作用
- Author:
Boquan JIN
;
Xuesong LIU
- Publication Type:Journal Article
- Keywords:
IL-2;
IL-6;
Thymocyte Proliferation;
Phenotype
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Murine thymocytes can be induced to proliferate and differentiate into cytotoxic effector cells when stimulated with Con A and provided with various cytokines. We have analysed the requirements for a range of cytokines in this system and, i n particular, the role of transforming growth factor ? (TGF-P) in regulating the cellular response to optimal concentration of the cytokines in combination. It was found that Con A+IL-2 (?)ed to marked proliferation and t hi s was augmented with IL-6, TGF-? inhibited the prolifera tion induced by IL-2+IL-6, the presence of TGF-?from the beginning of culture inhibited the development of cytotoxic effector cells and such effects were dose-related and could be reversed with antiserum to TGF-? but not. by a range of cytoki nes including IL-2, IL-4, IL-5, IL-6, TNF-a or ?-IFN. Phenotypic analysis indicated that TGF-? preferentially inhibited the expression of IL-2 receptor and the growth of ly2~+ cells.
