Antimetastatic activity of liposomes containing muramyl dipeptides activiated macrophages.
- VernacularTitle:脂质体—胞壁酰二肽激活巨噬细胞的抗肿瘤转移作用
- Author:
Linjie ZHANG
;
Liren YAO
- Publication Type:Journal Article
- Keywords:
Liposome Muramyl Dipeptide;
Macrophage;
Tumor;
Metastasis
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The in vitro tumoricidal activity of peritoneal macrophages harvested from C57BL mice and activiated by li posomes containing water-soluble muramyl dipeptides (MDP) was measured by ~(125)I.UdR release assay. The results demonstrated that liposomes containing MDP could effectively activiate macrophages to become tumoricidal. The percentage of pu(?)monarymetastasis and the average metastatic pulmonary colonies of mice with experimental tumor metastasis decreased after intravenous injection of MDP encapsulated in liposomes. These results suggested that systemic administration liposomes containing MDP whichinduced macrophage activiation might provide a useful immunot heray for tumor, especial1y for pulmonary mini metastasis.
