CLINICAL STUDY ON THE HYPOGLYCEMIC EFFECT OF GLIPIZIDE IN PATIENTS WITH TYPE II DIABETES MELLITUS
- VernacularTitle:吡磺环己脲对Ⅱ型糖尿病病人降糖作用的临床观察
- Author:
Binjie YU
- Publication Type:Journal Article
- Keywords:
Glipizide Type II diabetes mellitus Insulin secretion Glucose disposal constant (KI).
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Twenty-five type II diabetics failed to be controlled by diet therapy alone were treated with glipizide and followed-up for 6 months. The daily dose of glipizide ranged from 5-30 mg. The excellent or good glycemic control occurred in 88% and 72% of the patients respectively. No hypoglycemia and other side effects were observed. The areas of glipizide-glucose mediated insulin secretion did not show significant change before and after glipizide therapy, but the areas of glucose-mediated insulin secretion, the insulin sensitivity, and the glucose disposal constant(KI)were significantly higher after glipizide therapy. Our study indicated that the hypoglycemic effect of glipizide was not only due to improved islet B cell function in insulin secretion, but also due to enhanced insulin-induced glucose utilization and insulin sensitivity.
