THE ABNORMALITIES OF T CELL SUBSETS IN GRAVES' DISEASE
- VernacularTitle:Graves病患者T细胞亚群异常的研究
- Author:
Gong CHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
T cell can be divided into theophylline sensitive cell (TS) and theophylline resistant cell (TR) based on the E-RFC using human peripheral T cell treated with theophylline. The TS may be regarded as suppressor T cell and the TR helper T cell. T cell subsets were enumerated in 45 cases of Graves' disease(GD) and 22 normal controls. The results showed that the TR was significantly higher (56.63+7.03%) while the TS was.much lower (15.07+3.78%) in the patients than those in the controls (41.84+4.77% and 26.45+4.45% respectively). The TR/TS ratio of the pateints was elevated (4.16 + 1.76 vs 1.61 + 0.33) .The patients with normal serum T3, T4 after treatment of anti-thyroid drugs could be divided into-two subgroups, one with high and another with normal TR / TS ratio. TS function was determined using the mixed lymphocyte culture and the results were expressed as the suppressive rate (SR). The SR of the patients was singificantly lower than that of the controls (17.88 +2.52% vs 39.56 +3.22%). A positive correlation was found between the serum T3, T4 and TR / TS ratio of the patients. Our findings indicated that patients with GD may have immunological abnormalities in quantity and function of TS and the disturbance of immunoregulation might exist in Graves' disease.
