A PRELIMINARY STUDY ON BIOLOGICAL PROPERTIES OF THE MONOCLONAL ANTIBODY AGAINST HUMAN FIBRINOGEN
- VernacularTitle:抗人纤维蛋白原单克隆抗体生物特性研究的初步报告
- Author:
Airu LIU
- Publication Type:Journal Article
- Keywords:
Fibrinogen,Monoclonal Antibody.
- From:
Chinese Journal of Immunology
1985;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
This paper reports the biological characteristics of a group of anti-humanfibrinogen monoclonal antibody(McAb),termed HIF series,prepared in ourlaboratory.Results showed that some HIF McAbs reacted to human fibrino-gen and its fragments specifically no cross-reaction with human serum(1:5),bovin fibrinogen,rabbit plasma and serum was found expcept for HIF-4which expressed cross-reaction with rabbit plasma. A part of HIF McAbs(HIF-2,4,10)appeared precipitation band on immunodiffusion and immunoelectrophoresis test.It is possible that some HIF McAbsmight recognize multiple antigen determinats.Therefor,HIF series includeddiverse specificity of anti-fibrinogen. Some of HIF McAbs inhibited coagulation of blood,clot retraction and pla-telet aggregation.It is possible that the polymerization of fibrin monomer andthe bridge-binding action of plateles were inhibited by HIF McAbs,So thatHIF McAbs may be used to prevent high coagulation and thrombosis.
