RESPONSE OF GROWTH HORMONE TO TRH STIMULATION TEST IN THE DIAGNOSIS AND ASSESSMENT OF THERAPEUTIC EFFECT IN PITUITARY GH-SECRETING ADENOMA
- VernacularTitle:生长激素对TRH刺激的反应在垂体GH瘤诊断和疗效估计中的价值
- Author:
Yifan SHI
- Publication Type:Journal Article
- From:
Chinese Journal of Endocrinology and Metabolism
1985;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
The response of serum hGH to TRH stimulation was studied in 33 normal adults and 35 patients with pituitary GH-secreting adenoma before and after treatment. The results showed that a net increment of serum hGH level of mor than 6.0 ng / ml together with an increment of serum hGH over basal level by more than 50% should be taken as a positive response.After treatment with bromocriptine over 5 weeks, most of the response of serum hGH to TRH remained unchanged regardless of whether the basal hGH level bad decreased or not. The disease was remittent or cured in those whose TRH response became negative after pituitary surgery and / or pituitary radiotherapy. A persistent positive or possibly positive response after treatment suggested that the disease remained active. Tne results indicated that this test could be used as a tumor marker.The possible mechanisms responsible for the positive TRH test in acromegaly were discussed.
