A TOXICOLOGICAL STUDY ON LETHAL EFFECTS OF MONOCROTOPHO
- VernacularTitle:久效磷致死性效应的毒理学研究
- Author:
Yong LIU
- Publication Type:Journal Article
- Keywords:
~(14)C-monocrotopho;
lethal effects;
cholinergic activity;
radioactive activity
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
The relation ship between lethal effects and the distribution of monocrotopho contents in the body of mice has been showed by using tracer determination of radioisotope. The authors also observed the difference of degree of inhibited cholinergic activity in blood and brain of mice to which monocrotopho was given orally in different lethal dose. The results showed that there was a close relatiom between the death of monocrotopho acute poison and toxicant contents in brain. At the same time, wealso found there was no significant difference between the degree of inhibited cholinergic activity in blood and brain of survival mice to which monocrotopho was given orally in LD_(50) and dead mice in same dose as well as in excess lethal dose. This paper deals with the toxicological mechanism of the death of monocrotopho poison.
